The influence of old age on cardioprotective efficiency of pharmacological postconditioning using lactic acid in ischemia-reperfusion of the myocardium in experiment

Not only the prevalence, but also death rate from coronary heart disease, including myocardial infarction, is higher in older people than among young people. A demographic shift towards an aging population will lead to a further increase prevalence of cardiovascular diseases elderly population. Therefore, one urgent aims modern experimental and clinical medicine develop methods aimed at limiting reversible irreversible damage myocardium, patients. There are lot data supporting cardioprotective efficiency such phenomena as ischemic pharmacological pre- postconditioning that reduce reperfusion hearts. However, information on effectiveness these experiments old animals very scarce, contradictory, not fully understood. The aim study was experimentally evaluate influence age reproducibility using lactic acid ischemia-reperfusion myocardium. In course study, it found neutral lactate, after being administered into blood flow dose 10 mg/kg 25 minutes onset reperfusion, leads decrease infarct size left ventricle myocardium rats. Pharmacological lactate effective reducing duration cardiac arrhythmias rats; however, there tendency incidence total arrhythmias. obtained suggest presence risk factor for criterion exclude use with way ischemia injury